The Anti-Inflammatory Specialist: KPV

KPV (Lysine-Proline-Valine) is a potent C-terminal tripeptide derived naturally from alpha-MSH (alpha-Melanocyte-Stimulating Hormone). Renowned in peptide research for its strong anti-inflammatory, antimicrobial, and gut-protective properties, KPV offers researchers a targeted method to downregulate inflammatory cascades without the systemic hormonal actions of its parent molecule.

Note: This product is intended for  research use only.

KPV operates primarily as an intracellular messenger that quenches pro-inflammatory activity at the nuclear level:

• NF-κB Inhibition: Enters target cells directly to block the activation and translocation of NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells), the master switch for pro-inflammatory cytokine production.

• Cytokine Suppression: Significantly decreases inflammatory signaling molecules such as TNF-alpha, IL-6, and IL-1 beta.

• Antimicrobial Action: Interacts directly with bacterial and fungal cell walls (including Candida albicans), disrupting pathogen integrity while sparing healthy host tissues.

• Mucosal Protection: Crosses gut epithelial linings to soothe local inflammation, restore tight junction integrity, and protect the intestinal wall.

• Targeted Anti-Inflammatory: Downregulates inflammatory responses across dermal, gastrointestinal, and systemic tissue models.

• Gastrointestinal Health: Extensively studied in Inflammatory Bowel Disease (IBD) models for mitigating colonic inflammation and repairing mucosal lining.

• Antimicrobial & Antifungal: Demonstrates inherent broad-spectrum activity against pathogenic microbes without driving resistance.

• Accelerated Wound Healing: Reduces localized swelling and redness, facilitating clean tissue repair with minimal scar formation.

• Dermal Support: Studied for controlling inflammatory skin conditions like eczema, psoriasis, and contact dermatitis.

• Purity: >99% (HPLC tested to meet high-grade laboratory standards)

• Format: Lyophilized (freeze-dried) powder for maximum peptide stability

• Storage: Store in a cool, dry place away from direct light. Once reconstituted, it must be kept in the refrigerator to preserve the delicate bonds of the NAD+ and GHK-Cu molecules.